EMBLICA EXTRACT INDUCES TYPE I PRO-COLLAGEN SYNTHESIS AND INHIBITS COLLAGENASE ACTIVITY IN MOUSE FIBROBLASTS
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| Title | EMBLICA EXTRACT INDUCES TYPE I PRO-COLLAGEN SYNTHESIS AND INHIBITS COLLAGENASE ACTIVITY IN MOUSE FIBROBLASTS |
| Authors | |
| Abstract | Decrease of type I collagen generation as well as the increase of its degradation via matrix metalloproteinases (MMPs; e.g. gelatinases and collagenases) are considered as a major cause of skin aging. A potent natural antioxidant exblica extract from emblica fruits (Phyllanthus emblica) was herein evaluated for collagen promoting activity in mouse fibroblasts. We demonstrated that the level of intracellular type I pro-collagen increased following emblica extract treatment in concentration-dependent manner. Emblica extract at the concentration of 100 µg/mL exhibited the maximum effect on type I pro-collagen; approximately 7 fold-induction versus non-treated control determined by Western blot analysis. Moreover, our result indicated that emblica extract affected the MMPs function. Percentage of collagenase inhibition exceeded forty at the concentration of 100 µg/mL of emblica extract. Taken together, emblica extract has a promising anti-aging effect attributed to its positive effect on type I collagen formation as well as the protection against collagen degradation. |
| Publisher | African Ethnomedicines Network |
| Date | 2009-06-07 |
| Source | African Journal of Traditional, Complementary and Alternative medicines (AJTCAM) ABSTRACTS OF THE WORLD CONGRESS ON MEDICINAL AND AROMATIC PLANTS, CAPE TOWN NOVEMBER 2008 |
| Rights | Articles can be used for educational and non-comercial purposes. The copyrights of articles are retained by the authors with publication rights granted to AJTCAM. |