A Randomized Trial Of Oral Risperidone Versus Intramuscular Haloperidol In The Emergency Treatment Of Acute Psychotic Agitation
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| Title | A Randomized Trial Of Oral Risperidone Versus Intramuscular Haloperidol In The Emergency Treatment Of Acute Psychotic Agitation |
| Authors | |
| Abstract | Objective: The study aimed to compare the efficacy and tolerability of oral risperidone and oral clonazepam with intramuscular haloperidol and oral clonazepam in Filipino patients with acute psychotic agitation. Method: This study used a prospective randomized design targeting patients who were referred to the emergency department or hospital inpatients exhibiting both psychosis and agitation. Patients were randomized into oral risperidone group or intramuscular haloperidol group. Both groups received oral clonazepam as part of treatment. Patients were observed for 24 hours. The main efficacy parameter was the PANSS agitation cluster score. Other parameters were total PANSS, other PANSS subscale scores, time and incidence of additional clonazepam usage. The safety parameter measured as incidence of adverse events. Results: There were 99 subjects enrolled in the study: 49 in the oral risperidone arm and 50 in the intramuscular haloperidol arm. There were significant reductions in the mean PANSS agitation cluster scores for both groups: -7.6+4.7 for oral risperidone group (p |
| Publisher | ASEAN Federation of Psychiatry and Mental Health (AFPMH) |
| Date | 2011-07-14 |
| Source | ASEAN Journal of Psychiatry Vol 12, No 1 (2011): ASEAN Journal of Psychiatry |