Clozapine Re-Challenge With Lithium Supplementation Following Clozapine-Induced Neutropenia
|
| Title | Clozapine Re-Challenge With Lithium Supplementation Following Clozapine-Induced Neutropenia |
| Authors | |
| Abstract | Objectives: This paper aims to report on a case in which re-challenging with clozapine in combination with lithium in a patient who developed neutropenia was carried out. Methods: The patient was treated with clozapine for treatment-resistant schizophrenia. After five weeks he showed much improvement but developed neutropenia. Withdrawal of clozapine brought on a relapse of psychotic symptoms. Subsequently, clozapine was reintroduced along with Lithium. The neutrophil count was monitored closely. Results: The neutrophil and white blood cell count were noted to return to normal upon re-challenging, and the patientâs clinical condition also improved. Conclusion: Simultaneous administration of lithium and clozapine to patients experiencing neutropenia on clozapine is a possible strategy. However, very close monitoring of the white count is needed. ASEAN Journal of Psychiatry, Vol. 15 (1): January â June 2014: 90-92. |
| Publisher | ASEAN Federation of Psychiatry and Mental Health (AFPMH) |
| Date | 2013-11-12 |
| Source | ASEAN Journal of Psychiatry Vol 15, No 1 (2014): ASEAN Journal of Psychiatry |