COMPLEXES OF Zn(II) AND VO (IV) SULPHATES WITH KETO AND ENOL FORMS OF ISOBUTRYL ACETIC ACID, 4-AMINO BENZOIC ACID AND 4-CYANO BENZOIC ACID HYDRAZIDES .
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| Title | COMPLEXES OF Zn(II) AND VO (IV) SULPHATES WITH KETO AND ENOL FORMS OF ISOBUTRYL ACETIC ACID, 4-AMINO BENZOIC ACID AND 4-CYANO BENZOIC ACID HYDRAZIDES . |
| Authors | |
| Abstract | Abstract Metal complexes formed by the reactions of isobutryl acetic acid hydrazide[IBAH] , 4-amino benzoic acid hydrazide[4-ABAH] and 4-cyano benzoic acid hydrazide[4-CBAH] with manganese(II) and cobalt(II) ions were prepared and characterized by elemental analysis, conductance measurements, i.r., and electronic absorption spectra studies. The results showed that the hydrazides reacted with the metal salts in 1:2 molar ratio in all the complexes and acts as neutral bidentate ligands. The solubility test on the ligands and its metal(II) complexes revealed their solubility in ethanol and dimethylsulphoxide (DMSO). The molar conductance of the ligands and metal(II) complexes measured are indicative of their non-electrolytic nature. The infrared spectra of the hydrazide showed that ʋ(C=O), the carbonyl stretching mode called “amide1” band, the coupling between the in-plane bending ʋ(N-H) and ʋ(C-N) called the “amide II” band and the stretching frequency for the amino group ʋ(NH2) all experienced shifts to lower wave numbers in the complexes suggesting the coordination of the moieties to the metal ions. The electronic spectra of the Zn(II) complexes exhibited only a high-intensity bands and are assigned to a charge transfer, while the absorption spectra of Vo(IV) complexes showed three absorption bands characterized of 2B2 → 2B1 transitions at 22,727-12,048 cm-1 which is consistent with square pyramidal geometry.The synthesized ligands, along with their metal(II) complexes, were screened for their in vitro antibacterial activity against three Gram-negative (Escherichia coli, Klebsiella Pneumonia and Pseudomonas aeruginosa,) and two Gram-positive (Streptococcus lactis and Staphylococcus aureus) bacterial strains. The results of these studies show the that the free ligand and its metal complexes show positive effect towards Staphylococcus aureus. The metal(II) complexes show more biological activity than their ligands in all the micro organisms tested. |
| Publisher | World Science Publisher |
| Date | 2012-06-07 |
| Source | 2167-0854 |
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