HYPOTENSIVE EFFECTS AND ACUTE TOXICITY PROPERTY OF METHANOL EXTRACT OF BAISSEA AXILLARIS HAU. LEAF ON ANIMAL MODELS
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| Title | HYPOTENSIVE EFFECTS AND ACUTE TOXICITY PROPERTY OF METHANOL EXTRACT OF BAISSEA AXILLARIS HAU. LEAF ON ANIMAL MODELS |
| Authors | |
| Abstract | The hypotensive and acute toxicity activities of methanol extract of B. axillaris leaves, obtained by Soxhlet extraction, were analyzed using animal models. The extract exhibited a dose-dependent reduction in rabbit blood pressure. Basal mean arterial pressure of 115.67±3.60 mmHg was progressively reduced to 106.22±3.13 and 69.3±2.59 mmHg by 2.5 and 20 mg kg-1 doses of extract respectively. Haematological parameters in Wister rats treated with 1, 2 and 4 g kg-1 of extract showed no significant difference (P>0.05). However, lethal dosage was obtained at 8 g kg-1. The results obtained showed that the extract has a blood pressure lowering effect. |
| Publisher | African Ethnomedicines Network |
| Date | 2009-06-07 |
| Source | African Journal of Traditional, Complementary and Alternative medicines (AJTCAM) ABSTRACTS OF THE WORLD CONGRESS ON MEDICINAL AND AROMATIC PLANTS, CAPE TOWN NOVEMBER 2008 |
| Rights | Articles can be used for educational and non-comercial purposes. The copyrights of articles are retained by the authors with publication rights granted to AJTCAM. |