HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF SALVADORA OLEOIDES IN NORMAL AND ALLOXAN-INDUCED DIABETIC RATS
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| Title | HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF SALVADORA OLEOIDES IN NORMAL AND ALLOXAN-INDUCED DIABETIC RATS |
| Authors | |
| Abstract | Diabetes mellitus is a heterogeneous primary disorder of the carbohydrate metabolism with multiple etiological factors that generally involve absolute or relative insulin deficiency or insulin resistance or both. All causes of diabetes ultimately lead to hyperglycemia, which is the landmark of this disease syndrome. Salvadora oleoides Decne. (Salvadoraceae family) commonly known, as meetha jal is an oil yielding medicinal and multipurpose tree. It is adaptable to arid and alkaline conditions. Leaves of Salvadora oleoides are used to relieve cough, employed in the treatment of enlarged spleens and low fevers. Leaves of Salvadora oleoides have been mentioned to possess anti-inflammatory, analgesic and antiulcer activity. The objective of the present study was to evaluate the hypoglycemic and hypolipidemic activity of an ethanolic extract of aerial parts (stem and leaves) of Salvadora oleoides in normal and alloxan induced diabetic rats. Diabetes was induced in albino rats by administration of alloxan monohydrate (120 mg/kg i.p.). Normal as well as diabetic albino rats were divided into groups (n=6) receiving different treatments consisting of the vehicle (control), the ethanolic extract (1 g and 2 g/kg b.w) and the standard antidiabetic drug tolbutamide (0.5 g/kg b.w.). Blood samples were withdrawn by cardiac puncture and were analysed for blood glucose and lipid profile on day 0, day 7, day 14, and day 21. The ethanolic extract of Salvadora oleoides showed significant reduction (P |
| Publisher | African Ethnomedicines Network |
| Date | 2009-06-07 |
| Source | African Journal of Traditional, Complementary and Alternative medicines (AJTCAM) ABSTRACTS OF THE WORLD CONGRESS ON MEDICINAL AND AROMATIC PLANTS, CAPE TOWN NOVEMBER 2008 |
| Rights | Articles can be used for educational and non-comercial purposes. The copyrights of articles are retained by the authors with publication rights granted to AJTCAM. |