Journal Title Acta Medica Iranica Journal Abbreviation acta Publisher Group Tehran University of Medical Sciences (TUMS) Website http://acta.tums.ac.ir

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Title	A new approach for the induction of vitiligo in mice
Authors	Zehtab T, ; Rafieii Tehranie S, ; Yazdanparast R,
Abstract	Tyrosinase has been recognized as a major autoantign in human vitiligo. Here we have shown that experimental autoimmune vitiligo can be induced by intradermal injection of mushroom tyrosinase emulsified in complete Freund’s adjuvant in C57BL/6 mice. The onse of vitiligo was characterized by hair hypopigmentation and total melanocyte depletion in the basal layer of the epidermis. Our results confirm that tyrosinase is the causative autoantigen in the genesis of autoimmune vitiligo.
Publisher	Tehran University of Medical Sciences
Date	2012-10-20
Source	Acta Medica Iranica Vol 38, No 1 (2000)

 

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