The effects of Quinpirole and Sulpiride on conflict responses in rat
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| Title | The effects of Quinpirole and Sulpiride on conflict responses in rat |
| Authors | |
| Abstract | In this investigation wer studied the effect of dopaminergic system on the conflict behavior in rat, using vogel’s test. The related drugs were injected intraperitonealy (IP), and produced the following results:Diazepam at doses of 0.5 and 1 mg/kg increased the lick –shock responses in the Vogel’s thest. Quinpirole (D2-Agnosit), at doses of 0.1 and 10 mg/kg, increased the confict responses, wheraes suplpirde (D2 Antagonist) did not affect them.Apomorphine (D1 and D2 agonist) had a biphasic effect on the conflict responses. This drug decreased the number of shoks at low dose (0.01 mg/kg) while increased them at high dose (1 mg/kg). Haloperidol at dose of 1 mg/kg reduced the conflit responses significantly. Administration of both sulpiride (30 mg/kg) and quinpirole (10 mg/kg) together, increase the confict responses.These results suggest that D2-receptor agonist drugs may exert anixolytic and D2-receptor antagonists may produce anxiogenic effects in rat. |
| Publisher | Tehran University of Medical Sciences |
| Date | 2012-10-20 |
| Source | Acta Medica Iranica Vol 38, No 1 (2000) |