SCLERODERMA IN PEDIATRIC AGE GROUP: REPORT OF 25 CASES
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| Title | SCLERODERMA IN PEDIATRIC AGE GROUP: REPORT OF 25 CASES |
| Authors | |
| Abstract | Scleroderma is a multisystem autoimmune connective tissue disease, cliaracterized by hardening of the skin. HV had 25 patients in the Iranian Pediatric Unit of Rheumatology over 10 years. There was female predominance iF.M = 4/1, 80% female, 20% male). The age of onest was from 6 months to 16 years, the mean age being 10 years. The symptoms and signs were: nonpitting edema in 16%, liard skin in . sclerosis of distal limbs in 72%, facial in 20%, atrophy, ami hypopigmentation or hyperpigmentation in 40%, telangiectasis (15%), subcutaneous calcification (10%), Raynaud´s phenomenon in 60%, digital ulceration (16%), muscle pain and weakness, arthralgia (30%). Rarer rnantfestantion included, dysphagia (16%), dyspnea (8%), cardiovascular disease, pericarditis, cardiomegafy, CHF (16%). Laboratory abnormalities included: anemia (80%), positive FAN A. > 40 (88%) ESR > 60 (40%) CRP + + + (40%). Skin biopsy documented increase in the collagen content of dermis in 75%. |
| Publisher | Tehran University of Medical Sciences |
| Date | 2012-10-20 |
| Source | Acta Medica Iranica Vol 37, No 2 (1999) |