Journal Title Acta Medica Iranica Journal Abbreviation acta Publisher Group Tehran University of Medical Sciences (TUMS) Website http://acta.tums.ac.ir

PDF (506 kb)

Title	SPECTROSCOPIC STUDIES OF INHIBITION OF CALMODULIN ACTIVITY BY SOME DRUGS
Authors	Naderi, ; G., ; Farzami, ; B. Moosavi Movahedi, ; A.A.,
Abstract	The effect of four inhibitors on calmalulin (CuM) were studied by a ftuorescence and ultraviolet techniques. Four compounds IN - ( 6 - aminohexyt) 5-chloro - I - napthalenesulphonamide] (W-7), 1 - [ bis - (4 - chtorophenyt) methyl] - 3 - [2, 4-dichloro - β - ( 2 , 4 - dichlorobenzyloxyl) phenethyt] imidazolium chloride (R24571), trifluoperazine (TFP) , thiodiphenylamide chloride (TDPAC) showed inhibitory effect on bovine brain phosphodiesterase (PDE) induced by CaM. The concentration of inhibitors producing 50% inhibition of of Ca 2+ / CaM activity activity (IC50) and the Hill coefficient were correlating closely between the methods, Ki´s and thermodynamic parameters for these interactions were estimated.
Publisher	Tehran University of Medical Sciences
Date	2012-10-20
Source	Acta Medica Iranica Vol 34, No 1-2 (1996)

 

See other article in the same Issue