A SINGLE CENTRE RETROSPECTIVE 5 YEAR SURVEY OF INFECTIOUS COMPLICATION IN 85 CHILDREN WITH COMBINED IMMUNODEFICIENCY
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| Title | A SINGLE CENTRE RETROSPECTIVE 5 YEAR SURVEY OF INFECTIOUS COMPLICATION IN 85 CHILDREN WITH COMBINED IMMUNODEFICIENCY |
| Authors | |
| Abstract | Children with primary Tslymphocyte deficiency arc more ."I/."´clptihfe to infection hy organisms such (15: bacteria, fungi. prolo:o(J lind virus, 1711.´ isniatian oj all opponuniuic ory;ani."m or an IImallally severe infection with higher grade pathogens, provide a clue (0 diagnosis of immunodeficiency, To determine the microorganisms causing recurrent or severe infections in children with T•(rmpllOcy!e doflcicncy, we carried out II retrospective case review oj H5 patients with 1´../ympllOC)´te deficiency who wuc investigated at the Great Ormond Street Hospital for Children, NHS Trust, OH´r the 5 year period between June I, 11)88 and June I, 11)93. Tuc /:mllp of patients included 53 mules anti 32 [cmales, among which 23 and 62 were diagnosed to prewnt SClf) (/",1 elf) subtypes respectively, Among the 174 organisms isolated. these included bacteria (97 isolates], viruses (43 isolates}, funJ:i (25 isolates] and parasites (9 isolates}, 17lC predominant ."ites of infections were mainly the gll."trointe."titwl (60 out of 174) and respiratory tracts (49 out of 174). 171£´ most common bacterial infections, were with aerobic gram negative organisms (28 isolatcs), P.H´UdOmOnllS aeruginosa (17 isolates], Enterococcus (/2 isolates), C. difficile (10 isolates], Analysis: of 43 viral infection showed that Homvirus (10 isolates], Adenovirus (9 isolates], Herpes simplex (6 isolates], am!C}loml´!:altH´iTlH (6 isalatcs), Wi´rl! prrdominutu pathogens. Candida albicans was IIII´ most commonly isolated fungi. Parasitic infections included P. curini and Cryp(o."poridillm, 3 and (j opt of 9 cases. In our }iTOUp of pmients 16 patients´ died before hone maTOOW transplantation, due to infectimu complication. Based on this ."tlldy. we ,wgge.lt thai pronytaxis aJjllin.rt bacterial, viral, Jllngal ami protozoa agents is a necessity to minimize infectious complication." in 7~/ympilOcyte deficient patients, awaiting a hone marrow transplantation. |
| Publisher | Tehran University of Medical Sciences |
| Date | 2012-10-20 |
| Source | Acta Medica Iranica Vol 34, No 1-2 (1996) |