Erythropoietin may Modify Tyrosine Kinase Activity for its Neuroprotective Action in Mice
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| Title | Erythropoietin may Modify Tyrosine Kinase Activity for its Neuroprotective Action in Mice |
| Authors | |
| Abstract | The neuroprotective effect of erythropoietin (EpO) was evaluated against MgCl2 induced cerebral ischemia. EpO (500 IU/kg i.p) prevented the MgCl2 (0.5M) induced cerebral ischemia in the mice. EpO also reduced the bleeding time in mice by 7.64 %. Pretreatment with tyrosine kinase inhibitor, Genistein (6mg/kg i.p) attenuated the neuroprotective effect of EpO and reversed the effects of EpO on bleeding time in mice. These studies suggest that EpO is protective against MgCl2 induced cerebral ischemia and a role for tyrosine kinase enzyme in this action is suggested based on the results of this study. |
| Publisher | Indian Society for Education and Environment (ISEE) |
| Date | 2010-01-01 |
| Source | Indian Journal of Science and Technology Volume 3, Issue 1, January 2010 |